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陈赤副教授简介


  发布时间: 2017-01-05   信息员:   

陈赤,男,1971年出生,博士,现任美国明尼苏达大学(University of Minnesota)食品与营养系副教授,福建农林大学闽江学者讲座教授,AAPS J客座编辑及营养、生化和药学领域二十余种杂志审稿人。主要研究方向为营养生化(Nutritional Biochemistry)和营养代谢 (Nutritional Metabolomics),发表SCI论文70余篇,文章被他人引用7000余次。

(一)主要研究领域和专长

基于自身在化学、生物化学、药物学和代谢组学的研究和学术背景,建立了一个营养代谢组学的研究室。在此平台上,开展自主研究和合作研究。自主研究课题包括酒精、可卡因、油炸用油、微藻在体内代谢以及其诱导的代谢。合作课题包括细菌移植、动物添加剂、吗啡、绿茶在体内代谢以及其诱导的代谢。

(二)主要研究成果

1. 发现并确认一个新的酒精代谢产物(乙酰牛磺酸),并解析其在体内合成通路。该代谢物在尿中水平可作为一个有效的生物标记物以显示体内醋酸的水平。

2. 解析了可卡因在大鼠和小鼠中不同的代谢通路,并证明其在小鼠中的代谢更近似于其在人体中的代谢。另外,发现可卡因诱导的肝毒性与抑制脂肪酸代谢有关。通过改善脂肪酸代谢,可抑制可卡因肝毒性。

3. 建立一个化学衍生方法(2-hydrazinoquinoline)以方便同步检测醛、酮和酸类代谢产物。该方法的可行性在一个化学诱导的一类糖尿病模型中已被证实。

4. 利用代谢组学方法,检查了在猪饲料中添加干燥精馏谷物可溶性残留物(Dry Distillers Grain Soluble: DDGS)的代谢效应。该研究发现其硫成份可在猪体内转化成含硫抗氧化剂,从而避免了DDGS中氧化脂质对猪体内抗氧化系统和维生素E的负面影响。

5. 利用代谢组学方法,检查了在猪饲料中添加油炸食物废油的代谢效应。该研究发现喂废油可诱发肝增生并诱导激活PPARα相关的代谢通路。

6. 通过比较伪膜性结肠炎(C. difficile)患者在粪便移植前后的粪便样品,发现粪便移植对胆盐代谢的巨大影响,该结果已被应用于解释粪便移植对伪膜性结肠炎的治疗效果。

(三)近年主要学术成果

Kim JK, Gallaher DD, Chen C, Yao D, Trudo SP. Apiaceous vegetable consumption decreases PhIP-induced DNA adducts and increases methylated PhIP metabolites in the urine metabolome in rats. J Nutr. 145(3):442-51, 2015

Weingarden AR#, Chen C#, Bobr A, Yao D, Lu Y, Nelson V, Sadowsky MJ, Khoruts A. Microbiota Transplantation Restores Normal Fecal Bile Acid Composition in Recurrent Clostridium difficile Infection. Am J Physiol Gastrointest Liver Physiol. 306:G310-9 (2014) (# co-first author)

Liu P, Chen C, Kerr BJ, Weber TE, Johnston LJ, Shurson GC. Influence of thermally oxidized vegetable oils and animal fats on growth performance, liver gene expression, and liver and serum cholesterol and triglycerides in young pigs. J Anim Sci. 92:2960-70 (2014)

Lu Y, Yao D, Chen C*. 2-Hydrazinoquinoline as a derivatization agent for LC-MS-based metabolomic investigation of diabetic ketoacidosis. Metabolites. 3: 993-1010 (2013)

Song R, Chen C, Wang L, Johnston LJ, Kerr BJ, Weber TE, Shurson GC. High sulfur content in corn dried distillers grains with solubles (DDGS) protects against oxidized lipids in DDGS by increasing sulfur-containing antioxidants in nursery pigs. J Anim. Sci. 91: 2715-28, 2013

Wang L, Chen C*. Emerging Applications of Metabolomics in Studying Chemopreventive Phytochemicals. AAPS J. 15: 941-950 (2013)

Chen C*, Kim S. LC-MS-based metabolomics of xenobiotic-induced toxicities. Comput Struct Biotech J. 4:  e201301008 (2013)

Yao D, Shi X, Wang L, Gosnell BA, Chen C*. Characterization of Differential Cocaine Metabolism in Mouse and Rat through Metabolomics-guided Metabolite Profiling. Drug Metab Dispos. 41: 79-88, 2013 (*corresponding author)

Chen C*, Garlic and Cancer Prevention, Chapter 23 in “Inflammation and Cancer: Mechanisms and Dietary Approaches for Cancer Prevention” (ISBN 9781466503700, CRC Press) Publishing date: August 14, 2013

Cheng J#, Chen C#, Kristopher KW, Manna SK, Scerba M, Friedman FK, Luecke H, Idle JR, Gonzalez FJ. Identification of 2-piperidone as a biomarker of CYP2E1 activity through metabolomic phenotyping. Tox. Sci. 135: 37-47 (2013) (# co-first author)

Shi X, Yao D, Gosnell BA, Chen C*. Lipidomic profiling reveals protective function of fatty acid oxidation in cocaine-induced hepatotoxicity. J Lipid Res. 53: 2318-30, 2012 (*Corresponding author)

Shi X, Yao D, Chen C*. Identification of N-acetyltaurine as a novel metabolite of ethanol through metabolomics-guided biochemical analysis J Biol Chem. 287: 6336-49, 2012 (*Corresponding author)

Charves J, Chen C, Hegeman AD, Reineccius GA. Evaluation of instrumental methods for the untargeted analysis of chemical stimuli of orange juice flavor. Flavour and Fragrance J. 26: 429-440, 2011

Shu L, Cheung K, Khor TO, Chen C*, Kong AN. Phytochemicals: Cancer chemoprevention and suppression of tumor onset and metastasis. Cancer and Metastasis Reviews 29: 483-502 (2010)

Chen C, Krausz KW, Shah YM, Idle JR, Gonzalez FJ. Serum metabolomics reveals irreversible inhibition of fatty acid β-oxidation through the suppression of PPARα activation as a contributing mechanism of acetaminophen-induced hepatotoxicity. Chem Res Toxicol. 22: 699-707 (2009)


 

 

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